1. What is Total Iron Binding Capacity (TIBC)?

Total Iron Binding Capacity (TIBC) is a blood test that measures the blood's capacity to bind iron with transferrin. It represents the maximum amount of iron that can be carried in the blood serum. Normal TIBC values typically range from 250-450 µg/dL.

2. How is TIBC Calculated?

TIBC is calculated through laboratory measurement of transferrin saturation:

Where:

• TIBC — Total Iron Binding Capacity (µg/dL)
• Normal range — 250-450 µg/dL
• Transferrin — Iron-binding protein in blood

Explanation: TIBC reflects the total amount of iron that transferrin can bind, providing insight into iron metabolism and storage.

3. Importance of TIBC Measurement

Details: TIBC measurement is crucial for diagnosing iron-related disorders, including iron deficiency anemia, iron overload conditions, and monitoring response to iron therapy.

4. Using the Calculator

Tips: Enter your TIBC value in µg/dL to get an interpretation of your result. Values below 250 µg/dL or above 450 µg/dL may indicate underlying health conditions.

5. Frequently Asked Questions (FAQ)

Q1: What does low TIBC indicate?
A: Low TIBC may suggest iron overload (hemochromatosis), chronic diseases, malnutrition, or liver disease.

Q2: What does high TIBC indicate?
A: High TIBC typically indicates iron deficiency anemia, as the body produces more transferrin to maximize iron uptake.

Q3: How is TIBC related to transferrin?
A: TIBC indirectly measures transferrin levels, as each transferrin molecule can bind two iron atoms.

Q4: When should TIBC be tested?
A: TIBC should be tested when evaluating anemia, suspected iron disorders, or monitoring iron therapy effectiveness.

Q5: Are there factors that affect TIBC results?
A: Yes, pregnancy, oral contraceptives, inflammation, and certain medications can affect TIBC levels.