Total Iron Binding Capacity Calculated View Trends

TIBC Formula:

\[ TIBC = Transferrin (mg/dL) \times 1.25 (\mu g/dL) \]

Total Iron Binding Capacity (TIBC):

Unit Converter ▲

Unit Converter ▼

From:	To:

1. What is Total Iron Binding Capacity (TIBC)?

Total Iron Binding Capacity (TIBC) is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. It provides important information about iron status and metabolism in the body.

2. How Does the Calculator Work?

The calculator uses the TIBC formula:

\[ TIBC = Transferrin (mg/dL) \times 1.25 (\mu g/dL) \]

Where:

\( Transferrin \) — Serum transferrin concentration in mg/dL
\( 1.25 \) — Conversion factor to calculate TIBC in μg/dL

Explanation: Since each molecule of transferrin can bind two atoms of iron, the TIBC can be estimated from the transferrin concentration using this conversion factor.

3. Importance of TIBC Calculation

Details: TIBC is an important marker in assessing iron deficiency, iron overload conditions, and various anemias. Monitoring serial values over time helps track treatment response and disease progression in iron metabolism disorders.

4. Using the Calculator

Tips: Enter transferrin level in mg/dL. The value must be valid (transferrin > 0). For trend monitoring, record values over time to observe patterns in iron status.

5. Frequently Asked Questions (FAQ)

Q1: What is the normal range for TIBC?
A: Normal TIBC values typically range between 250-450 μg/dL, though reference ranges may vary slightly between laboratories.

Q2: How does TIBC relate to iron deficiency?
A: In iron deficiency anemia, TIBC is usually elevated as the body produces more transferrin to maximize iron binding capacity.

Q3: What conditions affect TIBC levels?
A: TIBC increases in iron deficiency, pregnancy, and estrogen therapy. It decreases in inflammatory conditions, malnutrition, and liver disease.

Q4: Why monitor TIBC trends over time?
A: Serial measurements help assess response to iron therapy, monitor chronic conditions affecting iron metabolism, and detect changes in nutritional status.

Q5: How often should TIBC be measured?
A: Frequency depends on the clinical situation. For monitoring iron therapy, it may be measured every 3-6 months. For chronic conditions, annual testing may be appropriate.