1. What Is Total Iron Binding Capacity (TIBC)?

Total Iron Binding Capacity (TIBC) is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. Low TIBC values may indicate possible iron overload conditions such as hemochromatosis.

2. How Does The Calculator Work?

The calculator uses the TIBC calculation formula:

Where:

• \( Transferrin \) — Transferrin concentration in mg/dL
• \( 1.25 \) — Conversion factor to calculate TIBC

Explanation: This formula calculates the theoretical maximum amount of iron that transferrin can bind based on its concentration in the blood.

3. Importance Of TIBC Calculation

Details: TIBC measurement is crucial for diagnosing iron metabolism disorders. Low TIBC values may indicate iron overload conditions, while high values may suggest iron deficiency anemia.

4. Using The Calculator

Tips: Enter transferrin concentration in mg/dL. The value must be valid (transferrin > 0). The calculator will automatically compute the TIBC value.

5. Frequently Asked Questions (FAQ)

Q1: What does low TIBC indicate?
A: Low TIBC may indicate possible iron overload conditions such as hemochromatosis, chronic diseases, or malnutrition.

Q2: What are normal TIBC values?
A: Normal TIBC values typically range between 250-450 µg/dL, though reference ranges may vary between laboratories.

Q3: How is TIBC related to transferrin?
A: TIBC is calculated from transferrin concentration since each molecule of transferrin can bind two atoms of iron, and the calculation uses a conversion factor of 1.25.

Q4: When should TIBC be measured?
A: TIBC should be measured when evaluating iron status, particularly when iron overload or iron deficiency is suspected based on other laboratory findings.

Q5: Are there limitations to this calculation?
A: This calculation provides an estimate. Actual TIBC measurement through direct laboratory testing may be more accurate in certain clinical situations.