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TIBC Formula:
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Total Iron Binding Capacity (TIBC) is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. It provides important information about iron metabolism and helps diagnose various iron-related disorders.
The calculator uses the TIBC formula:
Where:
Explanation: This formula provides an approximate calculation of TIBC based on transferrin levels, as each molecule of transferrin can bind two atoms of iron.
Details: TIBC measurement is crucial for evaluating iron status, diagnosing iron deficiency anemia, hemochromatosis, and other iron metabolism disorders. It helps differentiate between various types of anemia and guides appropriate treatment.
Tips: Enter transferrin concentration in mg/dL. The value must be valid (transferrin > 0). The calculator will provide TIBC in µg/dL.
Q1: What does a high TIBC value indicate?
A: Total iron binding capacity calculated is high typically indicates iron deficiency anemia, as the body produces more transferrin to maximize iron binding capacity.
Q2: What are normal TIBC values?
A: Normal TIBC values typically range between 250-450 µg/dL, though reference ranges may vary slightly between laboratories.
Q3: How does TIBC relate to transferrin saturation?
A: Transferrin saturation is calculated by dividing serum iron by TIBC and multiplying by 100. It represents the percentage of transferrin that is saturated with iron.
Q4: When should TIBC be measured?
A: TIBC is typically measured when evaluating suspected iron disorders, monitoring treatment response in iron deficiency, or assessing iron overload conditions.
Q5: Are there limitations to this calculation?
A: This formula provides an approximation. Direct measurement of TIBC may be more accurate in certain clinical situations, especially when transferrin levels are abnormal.