1. What Is Total Iron Binding Capacity?

Total Iron Binding Capacity (TIBC) is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. It reflects the maximum amount of iron that can be carried in the blood serum.

2. How Is TIBC Calculated?

TIBC is typically calculated using the formula:

Where:

• Transferrin — Measured in mg/dL
• 1.25 — Conversion factor to calculate TIBC

Explanation: This calculation estimates the total amount of iron that transferrin proteins in the blood can potentially bind.

3. Clinical Significance Of High TIBC

Medical Meaning: Elevated TIBC levels typically indicate iron deficiency anemia. When the body is iron-deficient, it produces more transferrin to maximize iron absorption and transport capacity.

4. Using The Calculator

Instructions: Enter the transferrin level in mg/dL to calculate the corresponding TIBC value in µg/dL. The result helps in assessing iron status and potential deficiency conditions.

5. Frequently Asked Questions (FAQ)

Q1: What does high TIBC indicate?
A: High TIBC typically suggests iron deficiency anemia, as the body produces more transferrin to compensate for low iron levels.

Q2: What are normal TIBC values?
A: Normal TIBC ranges are typically 250-450 µg/dL, though reference ranges may vary slightly between laboratories.

Q3: How does TIBC relate to transferrin?
A: TIBC is calculated from transferrin levels since transferrin is the primary iron-binding protein in blood plasma.

Q4: When should TIBC testing be performed?
A: TIBC testing is typically ordered when iron deficiency anemia is suspected, or when evaluating overall iron status and metabolism.

Q5: Are there conditions other than iron deficiency that affect TIBC?
A: Yes, TIBC can also be elevated in pregnancy, estrogen therapy, and acute hepatitis, though iron deficiency remains the most common cause.