Total Iron Binding Capacity Calculated From Serum Transferrin Concentration

TIBC Equation:

\[ TIBC (µg/dL) = Transferrin (mg/dL) × 1.34 \]

TIBC:

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1. What Is Total Iron Binding Capacity?

Total Iron Binding Capacity (TIBC) is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. It provides important information about iron metabolism and helps in diagnosing various iron-related disorders.

2. How Does The Calculator Work?

The calculator uses the TIBC equation:

\[ TIBC (µg/dL) = Transferrin (mg/dL) × 1.34 \]

Where:

\( Transferrin \) — Serum transferrin concentration in mg/dL
\( 1.34 \) — Conversion factor from transferrin to TIBC

Explanation: This calculation is based on the fact that each molecule of transferrin can bind two atoms of iron, and the conversion factor accounts for the molecular weight relationship between transferrin and iron-binding capacity.

3. Importance Of TIBC Calculation

Details: TIBC measurement is crucial for evaluating iron status, diagnosing iron deficiency anemia, hemochromatosis, and other iron metabolism disorders. It helps differentiate between various types of anemia and guides appropriate treatment.

4. Using The Calculator

Tips: Enter serum transferrin concentration in mg/dL. The value must be valid (transferrin > 0). The calculator will automatically compute the corresponding TIBC value.

5. Frequently Asked Questions (FAQ)

Q1: Why calculate TIBC from transferrin?
A: Calculating TIBC from transferrin provides a reliable estimate of iron-binding capacity without the need for direct TIBC measurement, which can be more time-consuming and expensive.

Q2: What are normal TIBC values?
A: Normal TIBC values typically range from 250-450 µg/dL in adults, though reference ranges may vary slightly between laboratories.

Q3: When is TIBC elevated or decreased?
A: TIBC is typically elevated in iron deficiency anemia and decreased in conditions like hemochromatosis, chronic diseases, or malnutrition.

Q4: Are there limitations to this calculation?
A: This calculation assumes normal transferrin function and may be less accurate in conditions with abnormal transferrin molecules or severe inflammation.

Q5: How does TIBC relate to transferrin saturation?
A: Transferrin saturation is calculated as (serum iron ÷ TIBC) × 100%, providing important information about iron availability and utilization.