1. What is TIBC?

Total Iron Binding Capacity (TIBC) is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. It provides important information about iron status in the body and helps diagnose iron deficiency or overload conditions.

2. How Does the Calculator Work?

The calculator uses the standard conversion formula:

Where:

• \( Transferrin \) — Measured transferrin level in mg/dL
• \( 1.25 \) — Standard conversion factor

Explanation: This calculation estimates the total iron binding capacity based on transferrin levels, which is the main iron transport protein in blood.

3. Importance of TIBC Calculation

Details: TIBC measurement is crucial for evaluating iron metabolism disorders. High TIBC typically indicates iron deficiency, while low TIBC may suggest iron overload conditions like hemochromatosis or chronic diseases.

4. Using the Calculator

Tips: Enter the measured transferrin value in mg/dL. The calculator will automatically compute the estimated TIBC and indicate whether iron deficiency is suggested based on typical clinical thresholds.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal TIBC range?
A: Normal TIBC typically ranges from 250-400 µg/dL. Values above 400 µg/dL often indicate iron deficiency.

Q2: Why is TIBC high in iron deficiency?
A: In iron deficiency, the liver produces more transferrin to maximize iron absorption and transport, resulting in higher TIBC.

Q3: How does TIBC relate to transferrin saturation?
A: Transferrin saturation is calculated as (serum iron ÷ TIBC) × 100%. It provides additional information about iron availability.

Q4: When should TIBC testing be performed?
A: TIBC is typically ordered when iron deficiency or overload is suspected, or as part of a comprehensive iron studies panel.

Q5: Are there limitations to this calculation?
A: While the formula provides a good estimate, direct measurement of TIBC may be preferred in certain clinical situations or when abnormal proteins are present.